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1. Outgoing FDA Chief Saw Changes to Food Safety, Tobacco Rules -

WASHINGTON (AP) – From food safety to tobacco regulation and politically charged drug approvals, Margaret Hamburg reset the course of the embattled Food and Drug Administration.

After nearly six years as FDA commissioner, Hamburg announced her resignation Thursday in an email to staff. She said the agency's chief scientist, Stephen Ostroff, will serve as acting head of FDA.

2. FDA Drug Approvals Reached 18-Year High in 2014 -

WASHINGTON (AP) – The Food and Drug Administration approved 41 first-of-a-kind drugs in 2014, including a record number of medicines for rare diseases, pushing the agency's annual tally of drug approvals to its highest level in 18 years.

3. Sponsors Pay Big Bucks to Join College Bowl Games -

SAN FRANCISCO (AP) – Ready! Set! Hut, hut: This holiday season's blitz of college football bowl games features a reshuffled roster of corporate sponsors spending millions to thrust their names in front of fans watching on TV and in the stands.

4. Survival of the Fittest -

Back in 2010, as the video rental giant Blockbuster was circling the drain in the wake of its Chapter 11 bankruptcy filing, the irony was inescapable to Matt Martin.

Martin, co-owner of Black Lodge Video in Memphis, told a reporter for the Christian Science Monitor how Blockbuster employees “literally laughed in our faces” when the independent video rental shop first opened its doors.

5. Why Experts Live in Fear -

More trouble has fallen upon companies that tempt the universe with this ego-inflated statement: "We are the experts.” A sizable lack of innovation occurs in the practice of being perceived as experts instead of practicing humility in the workplace.

6. AbbVie, Shire Agree on $55 Billion Combination -

The drugmaker AbbVie has reached a deal worth roughly $55 billion to combine with British counterpart Shire and become the latest U.S. company to seek an overseas haven from tax rates back home.

The companies said Friday they will create a new company that is incorporated on the British island of Jersey, where Shire currently is incorporated. But the new company will be controlled by shareholders of North Chicago, Illinois-based AbbVie, who will own about 75 percent of the new company's stock.

7. Applications Up for US Jobless Aid -

Slightly more Americans sought unemployment benefits last week, but claims for jobless aid continue to be anchored near seven-year lows.

The Labor Department said Thursday that weekly applications for unemployment benefits rose 8,000 to a seasonally adjusted 312,000. The four-week average, a less volatile measure, fell to 310,250. That’s the lowest average since June 2007.

8. Applications Up for US Jobless Aid -

Slightly more Americans sought unemployment benefits last week, but claims for jobless aid continue to be anchored near seven-year lows.

The Labor Department said Thursday that weekly applications for unemployment benefits rose 8,000 to a seasonally adjusted 312,000. The four-week average, a less volatile measure, fell to 310,250. That's the lowest average since June 2007.

9. Milestone Year -

The day after First Tennessee Bank celebrated its 150th birthday a few weeks ago by shooting fireworks over its Downtown Memphis headquarters, with executives and bank stakeholders mingling on a nearby hotel rooftop, the bank’s chairman, president and CEO looked back with pride at his bank’s long history.

10. Memphis Advertising Awards Get Campy -

Memphis’ advertising industry has been gearing up to go camping.

“Camp Addywanna” is the theme crafted by local agency inferno that will dominate the awards ceremony held next week by the American Advertising Federation’s Memphis chapter. The ceremony will be held Feb. 22 at the Memphis Zoo’s Teton Trek exhibit, and nearly every aspect of the event will include some allusion to a certain age-old ritual connected to youthful summers that involves tents, s’mores and hiking in the woods.

11. Panel Votes Down Heart Safety Claim for Naproxen -

SILVER SPRING, Md. (AP) – A majority of federal health experts said Tuesday that new research is not strong enough to conclude that naproxen, the pain reliever in Aleve and many other medications, is safer on the heart than rival drugs used by millions of Americans to treat arthritis and everyday aches and pains.

12. FDA Reconsiders Heart Safety of Common Pain Pills -

WASHINGTON (AP) – Federal health experts are taking a second look this week at the heart safety of pain medications used by millions of Americans to treat arthritis and other everyday aches and pains.

13. New Drug Approvals From FDA Declined in 2013 -

WASHINGTON (AP) – The Food and Drug Administration approved 27 first-of-a-kind drugs in 2013, down from 39 new medications in 2012, which was a 15-year high.

Despite the decline, FDA officials say the tally of innovative medications approved last year is in line with the historical trend. On average, the FDA has approved 28 first-of-a-kind drugs annually over the past five years.

14. FDA Overturns Safety Limits on Diabetes Drug -

WASHINGTON (AP) – The Food and Drug Administration is lifting severe safety restrictions on the former blockbuster diabetes pill Avandia, citing recent data suggesting that the much-debated medication does not increase the risk of heart attack.

15. Wal-Mart Ups Price Matching Before Holiday Start -

NEW YORK (AP) – Wal-Mart Stores Inc. says it's matching the Black Friday prices on a total of 100 toys and electronics from key rivals one week ahead of the traditional start.

16. Dish to Close Rest of its Blockbuster Stores in US -

SAN FRANCISCO (AP) – The final curtain is falling on the remaining Blockbuster video-rental stores that Dish Network Corp. runs in the U.S.

17. Airlines Promise a Return to Civility, For a Fee -

NEW YORK (AP) – Airlines are introducing a new bevy of fees, but this time passengers might actually like them.

Unlike the first generation of charges which dinged fliers for once-free services like checking a bag, these new fees promise a taste of the good life, or at least a more civil flight.

18. Cordova Building Sees Solid Leasing Activity -

The commercial building at 584 N. Germantown Parkway in Cordova has recently seen strong leasing activity. Advanced Prosthetics and Orthotics LLC, which opened in 2004 and provides prosthetic limbs and orthotics to support or supplement weakened or abnormal joints or limbs, inked a lease to occupy the 4,000 square feet of space that once housed a Baptist Memorial Health Care minor medical center. Last year, the center signed a 5,050-square-foot lease at the former Blockbuster space in Trinity Commons, 670 N. Germantown.

19. Measuring Innovation With Money -

But will it make real money? Innovation is such a heady, ill-defined concept. Innovation is one of those words – like strategy or creativity – that means either nothing or something different to anyone who hears it. But when handled correctly, genuine innovations are the lifeblood of any company’s continued health and success.

20. Steady Groove -

This year’s Record Store Day, an international celebration held the third Saturday in April, brought casual music fans along with diehards and vinyl evangelists into music shops around the country, including Goner Records and Shangri-La Records in Memphis.

21. Cestaro: Lab Will be First of its Kind -

TriMetis president Phil Cestaro took a year off after he resigned from Nashville-based SCRI Global Services at the Sarah Cannon Research Institute in 2011, where he was president.

“I didn’t know how much time I was going to take off, I just knew I was going to enjoy life and my family,” he said. “It was the best decision I ever made.”

22. Can Big Data Pay Off Big? -

Perhaps one of the most exciting advances in this decade is the emergence of big data, a collection of data sets so large they cannot be processed with standard database management programs. The analytics that companies glean from this data yield quantitative insight into business strategy that was previously unavailable. The world’s technological per-capita capacity to store information has roughly doubled every 40 months since the 1980s.

23. Ticket Rush: Film Fans Hand Hollywood Record Cash -

LOS ANGELES (AP) – The big deal for Hollywood is not the record $10.8 billion that studios took in domestically in 2012. It's the fact that the number of tickets sold went up for the first time in three years.

24. Retail Therapy -

The retail business has been described in recent times as Darwinian in nature to those in the industry, meaning formats come and go as competition intensifies each year.

That concept is apparent in retail chains having trouble finding the best real estate for new locations as antiquated strip centers retain high vacancies. Or in the resurgence of upscale retailers, while dollar stores are simultaneously expanding at a rapid clip.

25. Tuohy Shares Story at Lipscomb Pitts Event -

Some stories are so powerful that they don’t seem to get old, no matter how often they’re repeated.

That’s the effect Sean Tuohy’s remarks seemed to have on a crowd gathered for an evening reception Thursday, Nov. 15, at Independent Bank’s office tower in East Memphis.

26. LGSTX Services Expands Local Warehouse -

LGSTX Services Inc. is relocating and expanding its Memphis warehouse operations. The Wilmington, Ohio-based firm, which specializes in aviation support and facility services, has leased 184,680 square feet across two facilities in the Southwide Distribution area at 363 Burma Road and 410 Burma Road.

27. After Pandit, a Smaller Citigroup Could Get Smaller Yet -

NEW YORK (AP) – The incredible shrinking bank may have to shrink more.

In the hours after Tuesday's surprise announcement that Citigroup CEO Vikram Pandit was stepping down, speculation was rife, and facts scant, about what lay ahead for the nation's third-largest bank.

28. High Court Begins New Term With Human Rights Case -

WASHINGTON (AP) – The Supreme Court opened its new term Monday with a high-stakes dispute between businesses and human rights groups over accountability for foreign atrocities.

The justices appeared ready to impose new limits on lawsuits brought in U.S. courts over human rights violations abroad.

29. Film Industry Can’t Count on Incentives -

The discussion about film and video production incentives has come a long way from the days when incentives meant pile up the cash and push it across the table at the folks from Hollywood.

Tennessee Gov. Bill Haslam was lobbied hard when he was a candidate in 2010 to match what Louisiana was doing in film incentives. And to his credit, he took a hard line saying Tennessee shouldn’t get caught up in what amounted to an arms race for film and television production.

30. StyleCraft Signs Lease At Airways Building E -

Home decor company StyleCraft Home Collection Inc. has signed a 167,600-square-foot lease at Industrial Developments International’s Airways Distribution Center Building E.

31. Big-Box Vacancies Prove Hard To Fill -

The closing of big-box stores in recent years belonging to the likes of Borders Group Inc., Circuit City Inc. and others has left suburban shopping centers around the country with lots of space to fill.

32. Five Guys Opens New Locale in Bartlett -

Five Guys Burgers and Fries opened its second Memphis-area restaurant this week in Bartlett’s Stage Centre, 6600 Stage Road, suite 137.

33. Five Guys to Open 2nd Local Burger Joint -

Five Guys Burgers and Fries has inked its second Memphis-area lease – this one in Bartlett – and is close to solidifying two other locations, including one in Midtown.

Jubilee Restaurant Group LLC, owner of the Memphis franchise, has signed a 3,100-square-foot lease in Stage Centre. Five Guys is taking the subdivided end-cap of the 6,660-square-foot space formerly occupied by Blockbuster Video.

34. Take a Ride With ‘Biker’ Zinfandel -

A wine nicknamed “Biker” would probably conjure the idea of a burly, bearded guy wearing motorcycle colors, midnight black shades and an old German army helmet astride a powerful Harley, hurtling down the highway in a roar of power and arrogance. The Four Vines “Biker” Zinfandel 2009, Paso Robles, however, while being fairly burly, does not come across as a two-fisted, no-holds-barred blockbuster. In fact, there’s a certain paradoxical sense of balance and decorum about the wine, though it is undeniably forthright and flavorful.

35. Five Guys to Open 2nd Local Burger Joint -

Five Guys Burgers and Fries has inked its second Memphis-area lease – this one in Bartlett – and is close to solidifying two other locations, one in Midtown and another in Germantown.

Jubilee Restaurant Group LLC, owner of the Memphis franchise, has signed a 3,100-square-foot lease in Stage Centre. Five Guys is taking the subdivided end-cap of the 6,660-square-foot space formerly occupied by Blockbuster Video.

36. Gasol’s Path Leads Him To NBA All-Star Game -

People smiled and shook their heads. In high school gyms all across Shelby County, the curious came out to see the novelty act that was Pau Gasol’s younger brother and they dismissed the kid. If he looked soft playing for Lausanne Collegiate School against players a foot shorter and 100 pounds lighter – and he did – then he didn’t exactly project as an NBA player.

37. Verizon to Set Up Streaming Service With Redbox -

NEW YORK (AP) – Phone company Verizon Communications Inc. will challenge Netflix and start a video streaming service this year with Redbox and its DVD rental kiosks.

38. Renaissance 2012 -

It may be the start of a new year for most people, but for arts organizations in Memphis, it’s a new life altogether. Tough economic years in 2009 and 2010 led to creative collaborations in 2011, which some say will bloom into financial success in 2012.

39. Harbor Town Apts. Sell For $31.5M -

Dallas-based Behringer Harvard has acquired the Arbors Harbor Town Apartments – a 345-unit multifamily community in Harbor Town on Mud Island – for $31.5 million, or $91,304 per unit.

40. FDA Revokes Approval of Avastin for Breast Cancer -

WASHINGTON (AP) – The government delivered a blow to some desperate patients Friday as it ruled the blockbuster drug Avastin should no longer be used to treat advanced breast cancer.

Avastin is hailed for treating colon cancer and certain other malignancies. But the Food and Drug Administration said it appeared to be a false hope for breast cancer: Studies haven't found that it helps those patients live longer or brings enough other benefit to outweigh its dangerous side effects.

41. Capitoline Moves To SE Memphis Center -

A Rome, Ga.-based surface components manufacturer is relocating its distribution facility to the Southeast Memphis industrial submarket.

Capitoline Products has signed a 23,500-square-foot lease at 5805 Advantage Cove, confirmed the firm’s co-owner, L.G. Smith. The company is currently located off Lamar Avenue.

42. FDA Approves First Diabetes-Cholesterol Combo Pill -

TRENTON, N.J. (AP) – The first combination pill for the millions of people with the dangerous combination of diabetes and high cholesterol won U.S. approval Friday, offering convenience – and savings – to patients taking multiple pills.

43. Amazon Signs Deal to Stream Fox Movies -

SEATTLE (AP) – Amazon.com Inc. has signed a deal to stream Fox movies and TV shows including "24" and "Arrested Development" to members of its Amazon Prime premium shipping program.

44. Dish Takes Blockbuster Shot at Reeling Netflix -

SAN FRANCISCO (AP) – The Blockbuster video store chain is seeking some revenge against old nemesis Netflix by offering a less expensive way to watch videos online and rent DVDs through the mail.

45. Pfizer Q2 Net Up 5 Pct. on Lower Charges, Taxes -

Generic competition cut deeper into drugmaker Pfizer Inc.'s sales in the second quarter – with the U.S. patent expiration for its cholesterol fighter Lipitor, the world's top-selling drug, just five months away.

46. Drug Prices to Plummet in Wave of Expiring Patents -

The cost of prescription medicines used by millions of people every day is about to plummet.

The next 14 months will bring generic versions of seven of the world's 20 best-selling drugs, including the top two: cholesterol fighter Lipitor and blood thinner Plavix.

47. Survey: Most Pharmaceutical Execs Foresee More M&A -

TRENTON, N.J. (AP) – A survey of top executives of U.S. drugmakers indicates mergers and acquisitions should pick up in the next couple of years, as companies aim to offset rising generic competition.

48. Germantown Collection Sells for $7.3M in Foreclosure -

7810 Poplar Ave.
Germantown, TN 38138
Sale Amount: $7.3 million

Sale Date: June 23, 2011
Buyer: GA Poplar Avenue Germantown LLC (c/o Principal Real Estate Investors)
Seller: Jason A. Strain, substitute trustee
Original Borrower: CH Realty III/Germantown LLC
Original Lender: Principal Life Insurance Co.
Orig. Loan Amount: $8.7 million
Orig. Loan Date: Oct. 12, 2004

49. Principal Buys G’Town Collection for $7.3 Million -

The 60,724-square-foot Germantown Collection shopping center that includes tenants such as Chili’s and Panera Bread at the corner of Poplar Avenue and Exeter Road has been bought out of foreclosure.

50. Blockbuster Season -

Memphis’ Malco chain of theaters is in the final stages of converting its more than 300 screens to digital technology, a pricey upgrade that could broaden Malco’s ability to showcase more of the 3-D blockbusters Hollywood is primed to keep pumping out.

51. Pandora Gains Point to Healthy Internet IPO Future -

SAN FRANCISCO (AP) – Internet radio station Pandora Media's IPO struck the right chord with investors Wednesday despite the static in the overall stock market.

Pandora's shares surged by as much 63 percent in their market debut before pulling back later in the session. The stock closed at $17.42, still a decent gain amid the market's broader decline. It marked a 9 percent increase from Pandora's initial public offering price of $16 and a nearly six-fold increase from what Pandora's own board thought the stock was worth just six months ago.

52. Germantown Collection Center in Foreclosure -

The Germantown Collection shopping center that includes tenants such as Chili’s and Panera Bread at the corner of Poplar Avenue and Exeter Road has been foreclosed.

A first-run foreclosure notice for the 6.1 acre, Class A retail property appears in the Wednesday, June 1, edition of The Daily News and at The Daily News Online, www.memphisdailynews.com.

53. Senate: Sanofi Coordinated Lobbying by Physicians -

WASHINGTON (AP) – Drugmaker Sanofi gave millions of dollars to two medical societies which urged the Food and Drug Adminsitration to delay approving a low-cost version of the company's blockbuster blood thinner Lovenox, according to a Senate investigation released Wednesday.

54. Avaniel Perfect Companion for Barbecue Meal -

The Ribera del Duero wine region lies north of Madrid in Castilla y Leon on either side of the Duero river. In fact “Ribero del Duero” translates to “the banks of the Duero,” indicating how important that waterway is to grape cultivation in north-central Spain. In Portugal, the Duero becomes the Douro, which flows through the steep hillside vineyards of Port country. The red wines of Ribero del Duero, based primarily on the tempranillo grape, tend to be hearty, robust and flavorful, making them ideal to drink with – barbecue!

55. Cole Takes Reins Of Wolf River Conservancy -

Many Memphians might know that the Wolf River Conservancy is a nonprofit and land trust committed to conserving and protecting the Wolf River corridor as a natural sustainable resource.

What many do not know, however, is that, as of 2010, 10,000 adults and children were enrolled in educational and recreational programs either conducted or facilitated by the conservancy itself.

56. Dish Network's $228M Blockbuster Buy Approved -

NEW YORK (AP) – Blockbuster says a bankruptcy judge has approved Dish Network's $228 million offer for the movie-rental chain, paving the way for a combination of the two media companies.

57. Dish's Blockbuster Buy May Mean Brand's Survival -

NEW YORK (AP) – Dish Network Corp.'s agreement to buy Blockbuster Inc.'s assets out of bankruptcy could keep the movie-rental chain and its blue-and-gold logo from disappearing.

58. Icahn, Dish, Liquidators Vie for Blockbuster -

NEW YORK (AP) – Billionaire investor Carl Icahn, Dish Network and a pair of liquidation firms are among the bidders for video-rental chain Blockbuster in an auction Tuesday morning at U.S. Bankruptcy Court in New York.

59. Report: Dish, Icahn Join Bidding for Blockbuster -

NEW YORK (AP) – Several bidders are set to duke it out for Blockbuster Inc. at a bankruptcy auction in New York on Monday. They reportedly include Dish Network Corp. and billionaire investor Carl Icahn.

60. Yes! Reinvent the Wheel! -

If you are trying to invent something already invented, somebody, like my father, will say “Don’t try to reinvent the wheel, son.” For instance, when I was younger, I came across a strange-looking screw that wouldn’t work with what I knew to be a screwdriver, so Dad handed me a Phillips to replace mom’s kitchen knife I was trying to make work. “Don’t …….”

61. Judge Expected to Rule on Blockbuster’s Future -

A judge was expected to rule Thursday on whether movie-rental chain Blockbuster Inc., operating under Chapter 11 bankruptcy protection, can sell itself to a group of investors or will be forced to liquidate.

62. Family Dollar Signs 2 Leases for Stores -

Family Dollar has signed a 12,000-square-foot lease at 2754 Lamar Ave. Shawn Massey, partner with The Shopping Center Group LLC, represented the tenant. Harold Blockman with Keller Williams Realty Inc. represented the landlord, Chong K and Dul S. Pae.

63. Blockbuster Shuttering All Memphis Stores -

Some Hollywood films are so predictable, viewers can see the ending coming long before the credits roll.

In hindsight, consumers may decide the story of Blockbuster Inc. – the giant video rental chain that in a matter of days will no longer have a brick-and-mortar presence in Memphis – falls in that category.

64. Blockbuster Closing Last Two Memphis Storefronts -

In a matter of days, Memphians will no longer be able to visit a store and make it a Blockbuster night.

Every remaining Blockbuster store in Memphis is either closing or planning to close, signaling the end of the video rental chain's days in Memphis, the dominance of order-by-mail alternatives like Netflix and the convenience of kiosks like Redboxes.

65. Thriving Independent -

Matt Martin, co-owner of Midtown’s Black Lodge Video, said his proudly independent movie rental shop is looking to unveil a “midnight movie” series sometime this spring.

Still run by the same two guys who opened its doors in October 2000, Black Lodge also celebrated its 10-year anniversary a few months ago.

66. Oher to Sign Autobiography at Davis-Kidd -

Michael Oher, the central character of a Hollywood blockbuster whose inspiring story sees him go from the mean streets of Memphis to an NFL career, is now telling his story – his way.

Oher’s book “I Beat the Odds,” an account that focuses heavily on his early years in some of the poorest stretches of Memphis, will be released next month.

67. Blockbuster Closing Lakeland-Area Store -

Blockbuster Inc.’s local franchisee has closed another of its local brick-and-mortar rental stores.

The store at 9005 Highway 64 in Lakeland is holding a “store closing” sale and directing customers to stores near Germantown and Bartlett for future purchases.

68. Digital-Age Marketing -

People who are going to a Malco movie theater this weekend to see Hillary Swank as a lawyer in “Conviction” or big budget stars like Bruce Willis fighting bad guys in “Red” may notice a few changes around them.

69. Dolcetto d’Alba From Piedmont A ‘Sweet’ Choice With Light Fare -

Back in March, at the Barbera 2010 conference in Piedmont, I tried, among hundreds of other examples, two wines made from the barbera grape by Tenuta Cisa Asinari dei Marchesi di Gresy, to spell out the producer’s full name. Several months later, in Memphis, I encountered other wines from this historic estate as well as having the opportunity to chat with Alberto Cisa Asinari di Gresy, as charming and unassuming a personage as one could wish to meet or desire to emulate. His is the kind of family that can say, “Oh yes, we’ve owned that vineyard since 1797.”

70. Blockbuster’s Chap. 11 Won’t Impact Memphis -

NEW YORK (AP) – Blockbuster Inc., once the dominant movie rental company in the U.S., filed for bankruptcy protection on Thursday, reeling from mounting losses, rising debt and competitors that have better catered to Americans' changed media habits.

71. Schnucks Closure a Sign of Market’s Struggle -

News that the Schnucks supermarket at 1150 N. Germantown Parkway is closing brought to light an important realization about today’s economy.

72. Candidates Agree on Improving Small Biz Climate -

Whoever wins the Aug. 5 race for Shelby County mayor will inherit widespread dissatisfaction with county government’s small-business programs.

Small-business owners have complained that the Memphis and Shelby County programs are too bureaucratic, have nothing in common and are more trouble than they’re worth for the owners to get involved.

73. The Rise of Redbox -

Redbox, which is reshaping the U.S. video market with its massive horde of DVD kiosks and $1-per-day price strategy, is going on a tear in Memphis.

The company has filed 34 business licenses since Jan. 1, according to The Daily News Online, www.memphisdailynews.com. And that signals at least two things about the Oakbrook Terrace, Ill.-based division of Coinstar Inc.

74. Summer Movie Series Lights up Orpheum Stage -

The Broadway season is fading into the summer heat, but The Orpheum Theatre is just getting started on its annual Summer Movie Series offering air conditioning and audience participation in classic and “new classic” films.

75. Powerful Possibilities -

Oct. 29 turned into a day for window staring when the news came.

The top executives of GTx Inc. looked at the bleak gray of an overcast sky from the seventh floor of the Toyota Center, their minds gone blank.

76. Graceland Redevelopment Remains A Priority -

Memphis Mayor A C Wharton Jr. plans to roll out his first budget proposal next week to the Memphis City Council.

When he does, the mayor will draw on themes he has emphasized since taking office in October.

77. Pfizer Posts Big Jump in Q4 Sales, Profit -

TRENTON, N.J. (AP) - Drugmaker Pfizer Inc., well into integrating its new Wyeth unit, posted a 34 percent jump in revenue Wednesday, but $3.2 billion in acquisition and restructuring charges and higher costs across the board weighed down profit.

78. Blocked and Tackled -

The credits have rolled on a four-year-old legal drama between Dallas-based movie rental chain Blockbuster Inc. and the franchise group that runs Blockbuster stores in Shelby and Davidson counties.

79. GAO: FDA Yet to Make Safety Changes Post-Vioxx -

WASHINGTON (AP) - The U.S. Food and Drug Administration still hasn't restructured its staff to better monitor drug safety, more than three years after experts recommended key changes in the wake of the Vioxx scandal.

80. Vaccines on Horizon for AIDS, Alzheimer's, Herpes -

MARIETTA, Pa. (AP) - Malaria. Tuberculosis. Alzheimer's disease. AIDS. Pandemic flu. Genital herpes. Urinary tract infections. Grass allergies. Traveler's diarrhea. You name it, the pharmaceutical industry is working on a vaccine to prevent it.

81. Study: Global Prescription Drug Sales Growth Slows -

TRENTON, N.J. (AP) - Growth of prescription drug revenue worldwide will likely dip to between 4 percent and 6 percent next year – the lowest rate in at least a decade, according to a forecast to be released Thursday.

82. Blockbuster May Close as Many as 960 US Stores -

SAN FRANCISCO (AP) - Blockbuster Inc. may close as many as 960 stores by the end of next year, shedding more dead weight as the struggling video rental chain tries to reverse its losses and fend off rapidly growing rivals Netflix Inc. and Redbox.

83. Blockbuster Suit Meets With Failed Injunction Request -

The Dallas-based movie rental chain Blockbuster Inc. has won an early round in a three-year-old dispute between it and the franchise group that runs Blockbuster stores in Shelby and Davidson counties.

84. FDA Says Glaxo Vaccine Blocks Cancer-Causing Virus -

WASHINGTON (AP) - A vaccine from GlaxoSmithKline successfully blocks the virus that causes most cases of cervical cancer, the Food and Drug Administration said Friday.

In documents posted online, the FDA said Cervarix – Glaxo's vaccine against human papilloma virus or HPV – successfully blocked the two most cancerous strains of the virus nearly 93 percent of the time.

85. Pfizer to Pay Record $2.3B Penalty over Promotions -

WASHINGTON (AP) - Federal prosecutors hit Pfizer Inc. with a record-breaking $2.3 billion in fines Wednesday and called the world's largest drug maker a repeating corporate cheat for illegal drug promotions that plied doctors with free golf, massages, and resort junkets.

86. Merck, Schering-Plough in $42M Vytorin Settlement -

TRENTON, N.J. (AP) - Merck & Co. and Schering-Plough Corp. said Wednesday they will pay $41.5 million to settle lawsuits claiming the drugmakers, partners on two blockbuster cholesterol drugs, delayed unfavorable study results because they would hurt sales.

87. Wyeth Shareholders Vote to be Acquired by Pfizer -

Shareholders of drugmaker Wyeth on Monday voted overwhelmingly to be bought by industry giant Pfizer Inc., pushing aside one of the deal’s final hurdles.

88. Merck, Portola in $470M Deal for Anticlotting Drug -

TRENTON, N.J. (AP) - Merck & Co. and Portola Pharmaceuticals Inc. said Thursday they have signed an exclusive deal to develop and market an experimental drug to prevent strokes in people with a dangerous irregular heart rhythm.

89. Glaxo, Genmab Cancer Drug Gets FDA Panel Nod -

NEW YORK (AP) - GlaxoSmithKline PLC and its development partner Genmab came one step closer Friday to gaining approval on their cancer treatment Arzerra after an advisory panel recommended the Food and Drug Administration approve the therapy.

90. US High Court to Decide on Allowing Vioxx Suits -

The U.S. Supreme Court will decide whether shareholders can sue Merck & Co. over whether the drugmaker provided adequate information about the risks of its former blockbuster painkiller Vioxx before it was pulled from the market.

91. US Prescription Drug Use Fell in 2008, Study Says -

NEW YORK (AP) - Prescription drug use in the U.S. fell last year, although total spending on drugs increased as prices rose sharply on brand-name products, pharmacy benefits manager Medco Health Solutions said Wednesday.

92. US FDA Approves Dissolvable Version of Lamictal -

LONDON (AP) - The U.S. Food and Drug Administration has approved a dissolvable version of GlaxoSmithKline PLC's blockbuster drug Lamictal, the company said Monday.

Lamictal, or lamotrigine, is prescribed for the treatment of epilepsy or bipolar disorders. The company said a dissolvable version, which disintegrates on the patient's tongue, is important because people with those disorders can have a hard time swallowing pills.

93. Drugmaker Wyeth Posts Flat 1st-Quarter Profit -

TRENTON, N.J. (AP) - Drugmaker Wyeth, which is being acquired by drug giant Pfizer, on Wednesday posted a flat first-quarter profit but beat analysts' expectations, as cost cuts offset lower revenue, particularly for its top seller, blockbuster antidepressant Effexor.

94. Pfizer Profit Dips 2 Percent, Sales Fall Much More -

TRENTON, N.J. (AP) - Pfizer Inc. posted a 2 percent drop in first-quarter profit Tuesday, as cost-cutting by the world's largest drugmaker couldn't offset big drops in sales for several medicines, especially a big drop for the cholesterol fighter Lipitor.

95. After Gridlock, Blockbuster Suit Flares Anew -

Nothing probably seemed out of the ordinary to Blockbuster Inc. customers who visited the chain’s Memphis-area stores in the past few days looking for one of the week’s new releases, such as “Doubt” or “Yes Man.”

96. Bristol-Myers, Japanese Drugmaker Expand Deal -

TRENTON, N.J. (AP) - Drugmaker Bristol-Myers Squibb Co., seeking to bolster revenue during a crucial period, said Monday it has struck a deal with a Japanese partner to extend their partnership on one drug by 2 1/2 years and to collaborate on two others.

97. After 60 Years Circuit City Powers Down -

RICHMOND, Va. (AP) - What began 60 years ago as a humble television store in this sleepy Southern capital ended Sunday as Circuit City closed its doors for good – its 567 remaining U.S. stores to be left broom clean and vacant.

98. Pfizer to Buy Wyeth for $68B; Cut 8,000 Jobs -

TRENTON, N.J. (AP) - No. 1 drugmaker Pfizer Inc. said Monday it is buying No. 12 Wyeth for $68 billion in a deal that ultimately will wipe out nearly 20,000 jobs but quickly boost Pfizer's revenue and profit and transform it overnight into a medicine cabinet for all.

99. Report: US Drug Sales Growth Heads Toward New Low -

WASHINGTON (AP) - U.S. sales of pharmaceuticals will grow at the slowest rate on record this year, as the weakening economy compounds other factors hampering the industry, according to a report issued Wednesday.

100. $894 Million Deal Ends Pain of Pfizer's Lawsuits -

TRENTON, N.J. (AP) - Drug giant Pfizer Inc. has reached an $894 million deal to end most of the lawsuits over its two prescription pain relievers, the popular Celebrex and a similar drug, Bextra, no longer on the market.